Drug Standards
Sigma Aldrich Fine Chemicals Biosciences Temozolomide Related Compound A United States Pharmacopeia (USP) Reference Standard | 7008-85-7 | 15MG
Temozolomide Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 137.1 | 7008-85-7 | 15MG
Sigma Aldrich Fine Chemicals Biosciences Fenofibrate Related Compou50MG
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Sigma Aldrich Fine Chemicals Biosciences Tiamulin fumarate United States Pharmacopeia (USP) Reference Standard | 55297-96-6 | MFCD00145407 | 250MG
Tiamulin fumarate United States Pharmacopeia (USP) Reference Standard | Mol Wt: 609.81 | 55297-96-6 | MFCD00145407 | 250MG
Sigma Aldrich Fine Chemicals Biosciences Depramine United States Pharmacopeia (USP) Reference Standard | 58262-51-4 | 20MG
Depramine United States Pharmacopeia (USP) Reference Standard | Mol Wt: 314.85 | 58262-51-4 | 20MG
Medchemexpress LLC STAT3-D11-PROTAC-VHL | 96.3% | 1 MG
This PROTAC degrader targets Signal Transducer and Activator of Transcription 3 (STAT3). It exhibits anti-tumor activity with IC50 values of 1335 nM and 1973 nM against HeLa and MCF-7 cells, respectively. The compound binds to the DNA-binding domain of STAT3, recruits the E3 ligase VHL to form a ternary complex, leading to ubiquitination and subsequent degradation by the proteasome. It also inhibits tumor cell growth, induces cell cycle arrest and apoptosis, and suppresses tumor immune evasion.
- Degrades STAT3 transcription factor.
- Exhibits anti-tumor activity in HeLa and MCF-7 cells.
- Recruits E3 ligase VHL for STAT3 degradation.
- Inhibits tumor cell growth.
- Induces cell cycle arrest and apoptosis.
- Suppresses tumor immune evasion.
Medchemexpress LLC Oxfendazole | 53716-50-0 | MFCD00801063 | 98.8% | 1 G
Oxfendazole is a sulfoxide form of fenbendazole that is effective when taken orally. It fights parasites and has tumor-promoting activity.
- Appearance: White to off-white solid
- Purity: 98.8% (LCMS)
- Molecular Weight: 315.35
- Molecular Formula: C15H13N3O3S
- Consistent with structure by 1H NMR and LCMS
- Intended for laboratory chemicals and substance manufacturing
- For research use only
Sigma Aldrich Fine Chemicals Biosciences S-Nitroso-N-acetyl-DL-penicillamine | 67776-06-1 | MFCD00272624 | 25 mg
S-Nitroso-N-acetyl-DL-penicillamine | Purity: ≥97% | Mol Wt: 220.25 | 67776-06-1 | MFCD00272624 | 25 mg
Medchemexpress LLC N-(4-((3,4-difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but- | 2223677-62-9 | 10mg
Afatinib impurity 32 is an impurity of Afatinib (HY-10261)
Medchemexpress LLC Losartan 10Mm 1Ml Solution | HY-17512-10MM/1ML SOLUTIN
Losartan 10Mm 1Ml Solution
Sigma Aldrich Fine Chemicals Biosciences Tribenoside impurity A European Pharmacopoeia (EP) Reference Standard | 53928-30-6 |
Tribenoside impurity A European Pharmacopoeia (EP) Reference Standard | Mol Wt: 490.59 | 53928-30-6 |
Apexbio Technology LLC Imatinib (STI571) 152459-95-5 100mg
Imatinib (STI571) (CAS 152459-95-5) is a small-molecule inhibitor targeting protein tyrosine kinases including Abl kinase platelet-derived growth factor receptor (PDGFR) and c-Kit It modulates kinase activity by inhibiting phosphorylation thereby regulating oncogenic signal transduction pathways Imatinib exerts its biological activity primarily by suppressing the phosphorylation activity of Abl kinase (IC50 0 025 M) PDGFR (IC50 0 1 M) and c-Kit (IC50 0 1 M) In cell-based assays Imatinib inhibits PDGFR phosphorylation induced by PDGF-AA and PDGF-BB and reduces c-Kit-mediated signal transduction involved in tumor cell proliferation Based on these pharmacological properties Imatinib holds research potential in oncology for investigating kinase-driven cellular processes and therapeutic interventions
Medchemexpress LLC Atazanavir sulfate | 229975-97-7 | 802.93 | 1 ML
Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor. It acts as a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir also inhibits SARS-CoV 3CL pro with an IC50 of 3.49 μM. Additionally, Atazanavir has been shown to inhibit cardiac fibrosis, hyperlipidemia, and induce malignant glioma cell death.
- Highly selective HIV-1 protease inhibitor
- Orally active
- Inhibits CYP3A4
- Inhibits P-glycoprotein (P-gp)
- Inhibits SARS-CoV 3CL pro
- Inhibits cardiac fibrosis
- Inhibits hyperlipidemia
- Induces malignant glioma death
![Alkali Scientific Folic Acid [Pteroylglutamic acid] [Vitamin M], 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000661364.jpg-250.jpg)
Alkali Scientific Folic Acid [Pteroylglutamic acid] [Vitamin M], 5 G
Folic Acid (Pteroylglutamic acid), also known as Vitamin B9, is a compound used in cell culture applications, supplied in a 5g quantity. Folic acid is essential for DNA synthesis, repair, and cellular division, making it a vital component in maintaining cell growth and function. In cell culture, folic acid is typically used to support the growth and proliferation of eukaryotic cells, particularly in mammalian cell culture systems. It is also utilized in research related to gene expression, cellular metabolism, and the study of folate metabolism in various biological systems. The 5g packaging is ideal for laboratories requiring consistent and stable folic acid supplementation in their cell culture medium.
Medchemexpress LLC 2,3,4,6-tetra-O-pivaloyl-alpha-D-glucopyranosyl bromide | 81058-27-7 | MFCD08275217 | 50g
Empagliflozin impurity 15 is an impurity of Empagliflozin (HY-15409)